Over time, Szilagyi’s OA treatment has changed. When first diagnosed, she tried vitamin supplements. As her hands became more painful, she switched to Celebrex (celecoxib), a prescription nonsteroidal anti-inflammatory drug (NSAID) which relieves pain and swelling. These days, she uses Voltaren Gel (diclofenac), a topical OTC NSAID. The point: Even if your OA progresses over time, treatments are progressing, too, and there’s every reason to believe they will help you stay active your whole life.